Caspase-1 builds a new barrier to infection
Article Abstract:
A new strategy for host defense in which caspase-1 promotes cell survival by activating a pathway that repairs the cellular damage inflicted by pore forming toxins is reported. Upon activation, caspase-1 processes the pro-inflammatory cytokines IL-1[beta] and IL-18, leading to their secretion, which contributes to the innate immune response and host defense.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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The inflammasome: First line of the immune response to cell stress
Article Abstract:
NALP3-inflammasome is a protein complex that stimulates caspase-1 activation to promote the processing and secretion of proinflammatory cytokines. New insights into the regulation of caspase-1 activity in the inflammatory response are discussed.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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