A bivalent chromatin structure marks key developmental genes in embryonic stem cells

Article Abstract:

The article proposes that bivalent domains silence developmental genes in embryonic stem (ES) cells while keeping them poised for activation and a striking correspondence is observed between genome sequence and histone methylation in ES cells, which become notably weaker in differentiated cells. These results highlight the importance of DNA sequence in defining the initial epigenetic landscape and suggest a novel chromatin-based mechanism for maintaining pluripotency.

Author: Lander, Eric S., Schreiber, Stuart L., Kamal, Michael, Bernstein, Bradley E., Xiaohui Xie, Wagschal, Alexandre, Mikkeisen, Tarjel S, Huebert, Dana J, Cuff, James, Fry, Ben, Meissner, Alex, Wernig, Marius, Plath, Kathrin, Jaenish, Rudolf, Fell, Robert
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
Chromatin, Nucleotide sequence, Base sequence, Genetic research, Structure, Embryonic stem cells

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Genomic maps and comparative analysis of histone modifications in human and mouse

Article Abstract:

Histone H3 lysine 4 di- and trimethylation and lysine 9/14 acetylation across the nonrepetitive portions of human chromosomes 21 and 22 and patterns of lysine 4 dimethylation for several orthologous human and mouse loci were analyzed. It was found that the DNA elements that direct the methylation represent only a small fraction of the region or lie at some distance from the site.

Author: Gingeras, Thomas R., Lander, Eric S., Schreiber, Stuart L., Kamal, Michael, Lindblad-Toh, Kerstin, Bekiranov, Stefan, Bernstein, Bradley E., Bailey, Dione K., McMahon, Scott, Huebert, Dana J., Karlsson, Elinor K., Kulbokas, Edward J., III
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
Comparative analysis, Histones, Chromosome mapping, Human chromosome 21

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Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

Article Abstract:

Results reveal tissue-specific differences in protein expression and networks of mitochondrial genes sharing functional and regulatory mechanisms. Data identify specific genes for mitochondrial DNA repair enzymes, biogenesis, and evolution of mammalian mitochondria.

Author: Lander, Eric S., Patterson, Nick, Mootha, Vamsi K., Mann, Mathias, Bunkenborg, Jakob, Olsen, Jesper V., Hjerrild, Majbrit, Wisniewski, Jacek R., Stahl, Erich, Bolouri, Marjan S., Ray, Heta N., Sihag, Smita, Kamal, Michael
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
United States, Denmark, Analysis, Physiological aspects, Genetic aspects, Genetic regulation, Protein synthesis, Mitochondria, Mitochondrial DNA, Protein biosynthesis

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Subjects list: Research
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