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A discordant sibship test for disequilibrium and linkage: no need for parental data

Article Abstract:

A discordant sibship test using data of all affected and unaffected siblings and suitable for linkage testing and linkage-disequilibrium testing is introduced. The sibship disequilibrium test (SDT) requires no parental data, but at least one affected sibling and one unaffected sibling are needed, and the test can be more powerful than the transmission/disequilibrium test (TDT) for testing linkage disequilibrium especially for disease prevalence.

Author: Laird, Nan M., Norvath, Steve
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
United States, Statistical Data Included, Planning, Mathematical models, Chromosome mapping, Genetic disorders, Genetic research, Experimental design, Research design, Linkage (Genetics)

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Efficient study designs for test of genetic association using sibship data and unrelated cases and controls

Article Abstract:

A study to know the most efficient study designs for test of genetic association using sibship data and unrelated cases and control is presented. The findings of the study will be helpful for researchers designing and analyzing complex disease-association studies and will facilitate genotyping resource allocation.

Author: Mingyao Li, Boenke, Michael, Abecasis, Goncalo
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2006
Pennsylvania, Genotype, Genotypes

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Pathway-based approaches for analysis of genomewide association studies

Article Abstract:

Pathway-based approach using microarray data analysis for genomewide association (GWA) studies is presented. This approach is important in interpreting GWA data for identifying complex diseases.

Author: Mingyao Li, Kai Wang, Bucan, Maja
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
DNA microarrays, Human genome, Single nucleotide polymorphisms

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Subjects list: Research, Usage, Genetic aspects, Genetic markers, Brothers and sisters
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