A novel all helix fold of the AP180 amino-terminal domain for phosphoinositide binding and clathrin assembly in synaptic vesicle endocytosis

Article Abstract:

Research has been conducted on the clathrin-mediated endocytosis. The role of this endocytosis in retrieving synaptic vehicles from the plasma membrane following exocytosis has been investigated and the results are presented.

Author: Mao, Yuxin, Quiocho, Florante A., Chen Jue, Maynard, Jennifer A., Zhang, Bing
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
United States, Statistical Data Included, Physiological aspects, Cell membranes, Plasma membranes, Cell research, Cytological research, Amines, Endocytosis, Exocytosis, Phosphoinositides, Phosphatidylinositols, Clathrin

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Crystal structure of Pl-Scel, a homing endonuclease with protein splicing activity

Article Abstract:

The crystal structure of the the yeast PI-Scel bifunctional protein was analyzed at 2.4 angstrom resolution to characterize the structure-function relationships of the protein. Analysis of the crystal structure of the yeast PI-Scel indicated the presence of a highly conserved amino acid residue in the nucleolytic active site. The bifunctional yeast protein also exhibited structural-functional duality and acted as a monomeric endonuclease.

Author: Duan, Xiaoqun, Quiocho, Florante A., Gimble, Frederick S.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
Enzymes, Proteins, Enzyme structure-activity relationships, Protein conformation, Restriction enzymes, DNA, DNA restriction enzymes

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Subjects list: Analysis
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