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A phosphatase controls the fate of receptor-regulated Smads

Article Abstract:

One of the long-standing questions in the transforming growth factor [beta] field is answered by identifying a phosphatase, PPM1A that directly dephosphorylates Smad2 and Smad3 to limit their activation. Results reveal that PPM1A affects transcription and biological responses downstream of Smad signaling.

Author: Xiao-Fan Wang, Schilling, Stephen H., Datto, Michael B.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
Growth factor receptors

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PPM1A functions as a Smad phosphatase to terminate TGF[beta] signaling

Article Abstract:

PPM1A/PP2C[alpha] is identified as a bona fide Smad phosphate with the help of a functional genomic approach. It is demonstrated that PPM1A/PP2C[alpha], through dephosphorylation of Smad2/3, plays a critical role in terminating TGF[beta] signaling.

Author: Xia Lin; Xueyan Duan, Yao-Yun Liang; Ying Su, Wrighton, Katherine H.; Jianyin Long, Min Hu; Davis, Candi M.; Jinrong Wang; Brunicardi, F. Charles, Yigong Shi; Ye-Guang Chen; Anming Meng; Xin-Hua Feng
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
Phosphatases, Genetic research

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Phy tunes: Phosphorylation status and phytochrome-mediated signaling

Article Abstract:

A type 5 protein phosphatase, PAPP5, which acts on a biologically active phytochrome, increasing its stability and affinity for a downstream signal transducer is studied. It is shown to enhance plant photoresponses.

Author: Rubio, Vicente, Xing Wang Deng
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
Protein research, Phytochrome

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Subjects list: Research, Phosphorylation
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