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Absconding with the chaperone: essential cyclophilin-Gag interaction in HIV-1 virions

Article Abstract:

The gag gene regulates the assembly and uncoating of human immunodeficiency-1 (HIV-1) virions by encoding Capsid proteins (CA) and cyclophilin A (CyPA) cytoplasmic proteins. The HIV-1 Gag polyproteins mediate the release of enveloped virions by collecting viral components such as genomic ribonucleic acid and Env glycoproteins which are necessary for virion assembly. Furthermore, a stable CyPA and CA complex in necessary for protein-protein interaction during the replication of HIV-1 virions.

Author: Luban, Jeremy
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
Physiological aspects, Glycoproteins, Viruses

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Can the immune response control HIV infection?

Article Abstract:

Living viruses can create the best immunity to human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). The epidemiological evidence that HIV-2 infection may prevent infection with HIV-1 means that a considerable degree of cross-protection is achievable. It shows that HIV mutational changeability may not be as grave a problem as it was supposed to be. For the time being, it looks improbable that live attenuated viruses will be used as vaccines in developed countries.

Author: Paul, William E.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
Simian immunodeficiency virus

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Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B

Article Abstract:

The interaction between cyclophilins (CyPs) A and B and the human immunodeficiency virus type 1 (HIV-1) Gag polyprotein Pr55-gag plays an important role in acquired immunodeficiency syndrowe (AIDS) immunopathology. CyPs play a significant role in directing proteins to proper locations within cells.

Author: Luban, Jeremy, Kalpana, Ganjam V., Bossolt, Karen Leigh, Franke, Ettaly K., Goff, Stephan P.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
Causes of, AIDS (Disease)

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Subjects list: HIV (Viruses), HIV, Cyclophilin, Research
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