Antagonism between C-EBP(beta) and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors

Article Abstract:

The role of the GATA cofactor Friend of GATA (FOG) in the differentiation of avian multipotent hematopoietic progenitors has been studied and it was found that multipotent cells express high levels of FOG mRNA. The high levels were quickly down-regulated upon their C/EBP(beta)- mediated commitment to the eosinophil lineage. A model in which C/EBP(beta) induces eosinophil differntiation of the coordinate direct activation of eosinophil-specific promoters and removal of FOG, a promoter of multipotency as well as a repressor of eosinophil gene expression.

United States, Denmark, Germany, Gene expression, Cytochemistry, Birds, Messenger RNA, Hematopoiesis

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PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors

Article Abstract:

A candidate for membership among transcription factors that mediate lineage commitment of multipotent hematopoietic precursors is the Ets family transcription factor PU.1 expressed in B and myeloid cells. This factor is involved in specific instructions directed to transformed multipotent hematopoietic progenitors to differentiate along the myeloid lineage. It appears that PU.1 brings on myeloid lineage commitment by suppressing a master regulator of nonmyeloid genes and activating at that time multiple myeloid genes.

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Distinct C/EBP functions are required for eosinophil lineage commitment and maturation

Article Abstract:

Differentiation for hematopoiesis depends on designation of multipotent progenitors to a certain lineage followed by the maturation of the designated cells. The role of C/EBP proteins in lineage choice of multipotent hematopoietic progenitors (MEPs) transformed by the E26 virus has been studied to better understand transcriptional events in the process. C/EBP can bring on myeloid and eosinophil lineage commitment. Transactivation-independent and transactivation-dependent C/EBP functions are necessary during eosinophil lineage designation and maturation respectively.

Leukemia research

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