Anterior duplication of the Sonic hedgehog expression pattern in the pectoral fin buds of Zebrafish treated with retinoic acid

Article Abstract:

Ectopic expression of the Sonic hedgehog (shh/vhh-1) gene on the anterior margin of the bud below the apical ectoderm ridge is caused by the administration of retinoic acid (RA) to the zebrafish embryos during the beginning of the pectoral fin bud formation. Abnormal morphology of the fin buds and ectopic expression of shh/vhh-1 in the floor plate cells of the caudal end of the neural keel is also seen. The results of this study show that the beginning stages of the development of the limbs in fish and tetrapods are similar.

Observations, Ichthyological research, Ichthyology

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Anteriorization of CRABP-I expression by retinoic acid in the developing mouse central nervous system and its relationship to teratogenesis

Article Abstract:

Retinoic acid changes the normal distribution of cellular retinoic acid binding protein I (CRABP-I) in the developing mouse brain. Initially, CRABP-I is expressed in the hindbrain and the neural crest. Retinoic acid treatment upregulates CRABP-I expression and anteriorizes it. Retinoic acid may have a similar effect on Hox genes.

Carrier proteins, Transport proteins, Teratogenesis

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