SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival
Article Abstract:
The inositol 5-phosphatase SHIP plays a key role in down-regulating serine/threonine protein kinase B, or PKB. Studies of SHIP-deficient mice show market levels of myeloid cell hyperplasia in the spleen and bone marrow. Organs exhibited myeloid infiltration. SHIP-deficient myeloid cells are not significantly affected by growth factor withdrawal and sustain high levels of PKB activation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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Yeast autonomously replicating sequence binding factor is involved in nucleotide excision repair
Article Abstract:
Research was conducted to identify and characterize the autonomously replicating sequence binding factor 1 (ABF1) from yeast. Data indicate that ABF1 is a DNA-binding protein and plays a direct role in nucleotide excision repair in yeast.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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