Araucan and caupolican, two members of the novel iroquois complex, encode homeoproteins that control proneural and vein-forming genes

Article Abstract:

The achaete-scute (ac-sc) proneural genes and rhomboid (veinlet) in Drosophila imaginal wing discs are responsible for the high degree of pattern resolution that prefigure in the positions of sensory organs and wing veins in Drosophila. These genes have been found to contain a prepattern regulating factor that allows for the expression of the patterns. The homeoproteins Araucan and Caupolican have been found to be present in the domains of the imaginal discs. The homeoproteins are part of the iroquois allele which regulates ac-sc expression.

Genetic regulation

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Nuclear translocation of Extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein

Article Abstract:

Experiment was conducted to show that homothorax (hth) is required for the Hos genes to pattern the body of the fruit fly, Drosophila melagonaster. Hth plays a crucial role in the nuclear localization of an essential HOX cofactor, Extradenticle (EXD), and encodes a homeodomain protein which shares extensive identity with the product of MEIS1, a murine proto-oncogene. Data indicate a mechanism for the regulation of HOX activity where an EXD-HTH protein-protein interaction results in EXD's nuclear translocation.

Cell culture, Tissue culture, Developmental cytology

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The Iroquois homeodomain proteins are required to specify body wall identity in Drosophila

Article Abstract:

The Iroquois homeodomain proteins are necessary in Drosophila for the specification of body wall identity. Study findings indicate that a tergal phylogenetic origin exists for the more proximal part of the wing. Evidence of a novel pattern organizing center at the border of the apposed notrum Iroquouis complex-expressing (Iro-C expressing) and hinge (Iro-C-nonexpressing) cells was seen, with the border not a cell lineage restriction boundary.

Spain, Statistical Data Included, Developmental biology, Wings (Animal), Animal wings

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