Blood vessel formation: what is its molecular basis?

Article Abstract:

The discovery of vascular endothelial growth factors (VEGF) and fibroblast growth factor (bFGF) in endothelial cell cultures improved existing data on the genetic and molecular mechanisms that mediate vaculogenesis. The fibroblast growth factors mediate the formation of angioblasts from the mesoderm. On the other hand, the VEGF are expressed by angioblasts and endothelial cells during cell differentiation which leads to the formation of blood vessels. Furthermore, mutations in flk-1 gene leads to vascular malformations due to defective vaculogenesis.

Growth factors, Developmental biology, Fibroblast growth factors

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Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4

Article Abstract:

Vasculogenic and angiogenic developments of blood vessels are influenced by transmembrane ligand ephrin-B2 and its receptor. In the process of neovascularization, the transmembrane ligand ephrin-B2 and its receptor Eph-B4 disrupt arterial endothelial cells and venous endothelial cells respectively. Thus, the apparent distinctions of arteries and veins in the early stages of angiogenesis and onwards can be attributed to ephrin-B2 and its receptor.

Ligands (Biochemistry), Veins

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Vasculogenesis, angiogenesis, and growth factors: ephrins enter the fray at the border

Article Abstract:

Vasculogenesis refers to the earlier stages of vascular development which involves differentiation, expansion and coalescence of vascular endothelial cell. On the other hand, angiogenesis refers to the sprouting, branching and differential growth of blood vessels to form mature vascular patterns which can be seen in adult organism. Vasculogenesis requires VEGF and cell-specific receptor VEGFR2 while angiogenesis requires angiopoietins.

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