Brd4 links chromatin targeting to HPV transcriptional silencing
Article Abstract:
An E2 complex from human cells conditionally expressing HPV-11 E2 is isolated to identify cellular proteins involved in E2-mediated transcriptional repression. The double bromodomain-containing protein Brd4, which is implicated in cell cycle control and viral genome segregation, was found associated with E2 and conferred on E2 the ability to inhibit AP-1-dependent HPV chromatin transcription in an E2-binding site-specific manner as illustrated by in vitro repression of HPV transcription.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
RSC, an essential, abundant chromatin-remodeling complex
Article Abstract:
The RSC 15-subunit chromatin-remodeling complex of Saccharomyces cerevisiae was isolated and analyzed by mass spectrometric and limited peptide sequencing techniques. The RSC protein composed three subunits that are more homologous to human SWI/SNF components compared to yeasts SWI/SNF components. Furthermore, the adenosine triphosphate-dependent chromatin remodelling activities of RSC and SWI/SNF are activated by single-stranded or double-stranded nucleosomal deoxyribonucleic acid.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
Mesenchymal to epithelial conversion in rat metanephros is induced by LIF
Article Abstract:
Mesenchymal-to-epithelial conversion in metanephros of rats, brought on by leukemia inhibitory factor (LIF), is discussed. Ureteric bud cell lines (UB cells) were developed to serve as a surrogate for the embryonic ureteric bud. UB cells were found to secrete several additional factors that trigger the conversion in the presence of mesenchymal growth factors. Nephrons are formed. IL-6 cytokines are candidate regulators of mesenchymal-to-epithelial conversion in kidney development.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Coordination of replication and transcription along a Drosophila chromosome. Drosophila argonaute-2 is required early in embryogenesis for the assembly of centric/centromeric heterochromatin, nuclear division, nuclear migration, and germ-cell formation
- Abstracts: Constricting restricted transcription: The (actively?) shrinking web. The locus control region is required for association of the murine beta-globin locus with engaged transcription factories during erythroid maturation
- Abstracts: Histone trimethylation and the maintenance of transcriptional on and off states by trxG and PcG proteins. Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells
- Abstracts: Histone trimethylation and the maintenance of transcriptional on and off states by trxG and PcG proteins. part 2
- Abstracts: The best of times, the worst of times. Optioning your drugs