Control of MAP kinase signaling specificity or how not to go HOG wild
Article Abstract:
Mitogen-activated protein kinase (MAPK) cascades are central to many signal transduction pathways in eukaryotic cells. Studies of yeast cells have given new information. The cascades in yeast cells number five, of which two control response to solute concentration. One of those is the HOG pathway that orchestrates response to high osmolarity. More sharing of components for the mating filamentation and HOG pathways exists than had been previously thought. MAP kinases can serve as specificity factors.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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Synaptonemal complex morphogenesis and sister-chromatid cohesion require Mek1-dependent phosphorylation of a meiotic chromosomal protein
Article Abstract:
Yeast meiotic chromosome core development into full-length synaptonemal complexes must have the MED1 gene product which is a protein kinase homolog that is meiosis-specific. Fluorescent in situ hybridization analysis gives results that show that it is likely that Mek1-mediated phosphorylation of the Red1 protein is needed for meitoic sister-chromatid cohesion. Thus there is a possibility that cohesion is regulated by protein phosphorylation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
User Contributions:
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