A coat protein on phagosomes involved in the intracellular survival of mycobacteria

Article Abstract:

A study was conducted to determine the physiological function of the coat protein termed TACO in macrophage phagosomes. Results indicate that mycobacteria in macrophages lacking TACO proteins are readily transported to lysosomes and subsequently, degraded. On the other hand, macrophages with sufficient TACO proteins are observed to support the presence of mycobacteria. Hence, TACO proteins are found to play a vital role in the intracellular survival of mycobacteria.

Physiological aspects, Macrophages, Proteins, Mycobacteria, Mycobacterium

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Visualization of ER-to-Golgi transport in living cells reveals a sequential model of action for COPII and COPI

Article Abstract:

A chimera of the temperature-sensitive glycoprotein of vesicular stomatitis virus and green fluorescent protein (ts-G-GFPct) was used to visualize exocytic transport from the endoplasmic reticulum (ER) to the Golgi complex. Ts-G-GFPct concentrates into COPII-positive structures close to the ER, on shift to permissive temperature, forming an intermediate compartment containing ERGIC-53. This indicates a sequential mode of COPII and COPI action.

Observations, Endoplasmic reticulum, Exocytosis

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