DNA double-strand break repair: A relentless hunt uncovers new prey
Article Abstract:
Double-strand breaks (DSBs) are a dangerous form of DNA damage and the major pathway for repair of DNA double-strand breaks is nonhomologous end-joining (NHEJ). The discovery of a new NHEJ factor called Cernunnos-XLF is reported and the protein is mutated in a rare inherited human syndrome characterized by severe immunodeficiency, developmental delay, and hypersensitivity to agents that cause DNA double-strand breaks.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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TOPping up ATR activity
Article Abstract:
The nuclear protein kinase ATR is a key regulator of genome integrity that functions at checkpoints for damaged or incompletely replicated DNA. The molecular mechanism that controls ATR is highlighted and it is reported that physical interaction between ATR and a distinct domain of TopBP1 greatly enhances ATR kinase activity.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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Reconstitution of 5'-directed human mismatch repair in a purified system
Article Abstract:
Reconstitution of 5'nick-directed mismatch repair using purified human proteins is reported. The data suggest a model for human mismatch repair involving coordinated initiation and termination of mismatch-provoked excision.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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