DNA polymerase III: running rings around the fork
Article Abstract:
DNA polymerase III is a complex protein that is composed of ten subunits and is responsible for replicating the DNA strand as it unwinds into two parallel strands. The replication of two strands has been visualized as a simultaneous event that is initiated when a beta subunit forms a ring around the DNA and uncoils it. One strand is replicated directly while the other undergoes a sequential replication of fragments before being joined to form one strand. The efficiency of these mechanisms may be due to the close interactions between subunits and the DNA strands being replicated.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
Protein chainmail: catenated protein in viral capsids
Article Abstract:
The large size of oligomers produced during HK97 maturation is the reason why this bacteriophage's polypeptides are excluded from polyacrylamide gels after denaturation. Their enlargement is attributed to the intertwining of pentamer and hexamer rings before the covalent cross-linking of the bacteriophage's polypeptides. The adjacent protein rings catenate into a network similar to a chainmail armor. Such a structure is supported by experimental findings on the properties of these bacteriophages.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Polymerases and the replisome: machines within machines. IAP family proteins - suppressors of apoptosis
- Abstracts: RNA polymerase, PurR and MetR interactions at the glyA promoter of Escherichia coli. part 2 Expression and characterization of the prtV gene encoding a collagenase from Vibrio parahaemolyticus in Escherichia coli
- Abstracts: TGF beta 1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice