Distinct functions of junD in cardiac hypertrophy and heart failure

Article Abstract:

Cardiac hypertrophic stimuli induce both adaptive and maladaptive growth response pathways in heart. A study showing that the mice lacking junD develop less adaptive hypertrophy in heart after mechanical pressure overload, while cardiomyocyte-specific expression of junD in mice results in spontaneous ventricular dilation and decreased contractility is detailed.

Heart failure, Heart enlargement, Heart hypertrophy

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c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity

Article Abstract:

Partial hepatectomy (PH) experiments in several double-knockout mouse models are performed to genetically identify the signaling events regulated by the activator protein 1 (AP-1) transcription factor c-Jun. The results demonstrate that c-Jun/AP-1 regulates liver regeneration through a molecular pathway that involves p53, p21, and the stress kinase p38alpha.

Usage, Liver, Hepatectomy, Liver regeneration

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Liver tumor development: c-Jun antagonizes the proapoptotic activity of p53

Article Abstract:

Research has been conducted on transcription factor c-Jun which mediates cell survival and proliferation. Results demonstrate that c-Jun prevents apoptosis via antagonizing p53 activity possibly contributing to the early stages of human hepatocellular carcinoma development.

Austria, Analysis, Causes of, Physiological aspects, Genetic transcription, Transcription (Genetics), Cancer invasiveness, Cell research, Cytological research, Liver tumors, Hepatoma, Hepatocellular carcinoma, Apoptosis

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