Do changes in chromosomes cause aging?

Article Abstract:

Research has yet to determine the molecular events that cause aging. However, findings suggest that changes in chromosomal structure or function have a significant impact on the aging process. It is possible that aging may act at the cellular level because most organ dysfunction in aging is caused by a loss of cell function. In addition, primary explants of animal cells can only divide up to a certain number of times before becoming postmitotic. Specific genes that control the aging rate in Saccharomyces cerevisiae, Caenorhabditis elegans and human beings have been identified.

Aging

---

Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase

Article Abstract:

The genetic properties of the fuzzy onions (fzo) gene that encoded the mediator of mitochondrial fusion were analyzed in fzo mutants that exhibited defective postmeiotic fusion. Analysis of the fzo mutants indicated the role of the fzo in encoding a novel transmembrane guanosine triphosphatase (GTPase) that was associated with the spermatid mitochondria during the time of fusion. However, missense mutations in the conserved GTPase motifs reduced Fzo function.

Genetic regulation, Gene expression, Mitochondria

---

Riding the polar winds: chromosomes motor down East

Article Abstract:

The kinesin-related motor protein of the chromosome arms effect the chromosome position on the spindle. The chromosomes are blown out from the pole by the polar winds, and the kinesin-related motor proteins distributed along the chromosome may add to ejection. The binding of the microtubules to the chromosome could stabilize, organize and maintain the nonkinetochore microtubules between poles, and convert a pair of asters to spindle structure.

Analysis, Observations, Kinesin, Spindle (Cell division), Spindle (Cytoplasm)

Similar abstracts:

• Abstracts: Expression of the SmN splicing protein is developmentally regulated in the rodent brain but not in the rodent heart
• Abstracts: Stationary phase in the yeast Saccharomyces cerevisiae. Genetic regulation of phospolipid biosynthesis in Saccharomyces cerevisiae
• Abstracts: A defect in dolichol phosphate biosynthesis causes a new inherited disorder with death in early infancy. Mitochondrial phosphate-carrier deficiency: A novel disorder of oxidative phosphorylation
• Abstracts: undulated phenotypes suggest a role of Pax-1 for the development of vertebral and extravertebral structures. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo
• Abstracts: The planctomycetes: emerging models for microbial ecology, evolution and cell biology

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.