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Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex

Article Abstract:

A study was undertaken to find out whether in early pancreatic development, active PTF1a requires interaction with RBPJ, the vertebrate Suppressor of Hairless. Results showed that interaction between PTF1a RBPJ was important for the early stages of pancreatic growth besides morphogenesis and lineage fate decisions.

Author: Masui, Toshihiko, Magnuson, Mark A., Qiaoming Long, Beres, Thomas M., MacDonald, Raymond J.
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
Physiological aspects, Growth, Vertebrates, Morphogenesis, Pancreas, Company growth

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PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation

Article Abstract:

A study identifies PRMT6 as a mammalian methyltransferase for H3 R2 and establishes the enzyme to be a crucial negative regulator of H3 K4 trimethylation and transcriptional activation.

Author: Stein, Claudia, Bauer, Uta-Maria, Schiltz, Emile, Hyllus, Dawin, Schnabel, Kristin, Imhof, Axel, Dou, Yali, Hsieh, James
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
DNA repair, Gene expression, Methyltransferases

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Subjects list: Research, Genetic transcription, Transcription (Genetics)
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