Emotion: systems, cells, synaptic plasticity
Article Abstract:
Emotional responses are influenced by sensory stimuli that are processed in the neural circuitry of the brain. The neurological defense mechanism that detects and responds to fear/danger exhibits synaptic plasticity. This neuronic response to danger is mediated by the amygdala and its afferent and efferent neurons. Glutamatergic transmission and N-methyl-D-aspartate also mediates the mechanisms for memory and learning during the process of fear conditioning. The long term potentiation of synaptic activity is also dependent on glutamatergic transmission in the thalamo-amygdala pathway.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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Cerebellar LTD: a molecular mechanism of behavioral learning?
Article Abstract:
Long-term depression is associated with a molecular mechanism of behavioral learning. The establishment of gene-targeting knockouts changes the operation of neural circuits which generate behaviors. These circuits are not static and do not result from genetic codes without being influenced by environmental factors. However, molecular learning loss in the vestibulo-ocular reflex cannot be determined alone from molecular and behavioral studies because of neutral circuit abnormalities.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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Using genetic mutations to study the neural basis of behavior
Article Abstract:
The use of genetic mutations in examining the neural basis of behavior, specifically the mechanisms behind learning and memory, is presented. The applicability of several lesion techniques is influenced by their ability to satisfy three requirements, namely, component specificity, temporal specificity and behavioral specificity. A framework for the use of targeted mutations for better research of neural systems is described.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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