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Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease

Article Abstract:

Two human airway epithelial cell culture models were developed to study the pathogenesis of cystic fibrosis airways disease. These frameworks were used to differentiate the hypotonic (low salt) airway surface liquid/defensin hypothesis and the isotonic volume transport/mucus clearance hypothesis. These two theories explain the role of airway epithelial ion transport in lung defense and predict the impact of mutations in cystic fibrosis transmembrane conductance regulator. Findings did not show that the liquids lining airway surfaces were hypotonic or that salt concentrations were different between cystic fibrosis and normal cultures.

Author: Boucher, Richard C., Grubb, Barbara R., Tarran, Robert, Matsui, Hirotoshi, Randell, Scott H., Gatzy, John T., Davis, C. William
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
Analysis, Causes of, Lung diseases, Obstructive, Chronic obstructive lung disease, Epithelial cells, Cystic fibrosis, Salt (Food), Sodium (Nutrient), Salt in the body, Airway (Medicine), Airway

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Regulatio of Golgi structure through heterotrimeric G proteins

Article Abstract:

It has been shown that ilimaquinone (IQ), a marine sponge metabolite, can cause vesiculation of the Golgi stacks. It has also been shown that the process does not require ARF and coatomers. IQ-mediated Golgi vesiculation was found to be inhibited by Galphas-GDP and Galpha13-GDP, and that the free Betagamma triggers Golgi vesiculation.

Author: Takizawa, Peter A., Jamora, Colin, Zaarour, Rania F., Denesvre, Caroline, John Faulkner, D., Malhotra Vivek
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
Research, Golgi apparatus, Plant metabolites

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