Sequence alterations within CYP7B1 implicate defective cholesterol homeostasis in motor-neuron degeneration
Article Abstract:
The article discusses the identification of the sequence alterations in the cytochrome P450-7B1 (CYP7B1), the gene which is found to be highly associated with the hereditary spastic paraplegia (HSP). The results prove that such alterations lead to defective cholesterol homeostasis in motor-neuron degeneration.
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2008
Genetic aspects, Cholesterol metabolism, Paralysis, Spastic, Spastic paraplegia
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2008
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Simultaneouly correcting for population stratification and for genotyping error in case-control association studies
Article Abstract:
A method of simultaneously correcting for the bias arising population stratification and for genotyping error in case control studies was developed. Thus the corrected test is robust against misspecification of the genetic model.
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
United States, Evaluation, Population genetics, Genetic research
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
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Comment about this article or add new information about this topic:
Subjects list: Research
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