Evolutionary consequences of DNA mismatch inhibited repair opportunity

Article Abstract:

Homologous recombination is the primary process involved in repairing double strand breaks. Such a repair procedure will be affected by heterozygosity because of mismatch detection within the system. Molecular evolution can therefore be influenced by polymorphism-associated recombinational repair inhibition. Mismatch detection also poses a limitation on the average heterozygosity, leads to the generation of more rare variants and diminish the rate of neutral molecular evolution.

Chemical evolution, Molecular evolution

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DNA repair and the evolution of transformation in Haemophilus influenzae

Article Abstract:

A study was conducted to evaluate DNA repair hypothesis. Earlier studies assume that bacteria integrate DNA from similar or closely related species under certain environmental limits. These past results suggest that transformation evolved from DNA repair of damaged chomosomes. The current study tested the hypothesis on Haemophilus influenzae. Results of the experiment support the hypothesis but do not account for higher survival of transformed cultures.

Evolution (Biology), Microorganisms

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Evolution of natural transformation: testing the DNA repair hypothesis in Bacillus subtilis and Haemophilus influenzae

Article Abstract:

The DNA repair hypothesis was examined by evaluating the developmental regulation of competence as a factor of DNA damage. In this study, the competence for transformation of Bacillus subtilis and Haemophilus infuenzae as a result of exposure to UV irradiation and mitomycin C was determined. The results showed that no induction of competence occurred in response to DNA damage.

Bacillus subtilis

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