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An HMG1-like protein facilitates Wnt signaling in 'Caenorhabditis elegans'

Article Abstract:

A protein similar to HMG1 encourages Wnt signaling in gene transcription regulation. Using Caenorhabditis elegans as subjects, SON-1 exhibited HMG1-like traits such as cell fate transformation in several developmental processes, including somatic gonad development, male tail patterning and vulva development. SON-1 acts downstream within the Wnt signaling pathway, also similar to HMG1 activity.

Author: Sternberg, Paul W., Jiang, Lily I.
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
United States, Proteins, DNA binding proteins, Cell physiology

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A functional study of miR-124 in the developing neural tube

Article Abstract:

The chick spinal cord as an in vivo system was employed to investigate the role of miR-124 during neural development. It was found that neither inhibition nor ectopic expression of miR-24 markedly altered general neuronal differentiation, suggesting that miR-124 does not act as determinant of neuronal differentiation.

Author: Gage, Fred H., Pfaff, Samuel L., Xinwei Cao
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
Science & research, Genetic aspects, Developmental genetics, Developmental neurology

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