Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis
Article Abstract:
A Swedish Epidemiological Investigation of Rheumatoid Arthritis (EIRA) and North American RA Consortium (NARAC) was conducted to compare three different definitions of interaction between the two major genetic risk factors of rheumatoid arthritis (RA)-the histocompatibility complex, class II, DR beta 1 (HLA-DRB1) shared epitope alleles and the protein tyrosine phosphatase R620W allele. The linkage disequilibrium approach indicated a gene-gene interaction in EIRA and NARAC.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
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Enhanced response to enzyme replacement therapy in Pompe disease after the induction of immune tolerance
Article Abstract:
The vector-mediated gene therapy with adeno-associated virus (AAV) is capable of inducing tolerance to introduced glucosidase (GAA) and enhancing the efficacy of enzyme replacement therapy (ERT) in cross-reacting immunologic material (CRIM)-negative patients with Pompe disease and in patients with other lysosomal storage diseases.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
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Marfan syndrome: from molecules to medicine
Article Abstract:
Harry C. Dietz achieved the 2006 curt stern award address for his research on pediatric cardiology.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
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