Genomic evolution in mice and men: imprinted genes have little intronic content
Article Abstract:
A genetic report which concluded that imprinted genes have few and small introns was criticized by D. Haig as he claimed that the relative intronic content of genes negatively covaries with the GC% of their isochore. Haig proposed that linkage must be controlled in GC-rich isochores. However, researchers of the report contend that the observed covariance is between isochore group and intron size. They also refuse to support the idea that imprinted genes are over-represented in GC-rich isochores even as they doubt Haig's use of a sample size of only one in determining intron dimensions.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 1996
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High blood pressure: hunting the genes
Article Abstract:
Advances in molecular and cell biology has made possible the linking of genes to the etiology of hypertension. Using restriction fragment polymorphisms and analysis of chromosomal markers, research has shown that renin genes, angiotensin converting enzyme loci, lithium-sodium antiport systems, kallikrein, soidium-potassium-adenosine triphosphatase alpha-one and alpha-two subunits and established environmental factors interact to cause high systolic and diastolic pressures.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 1992
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Homeobox genes in vertebrate evolution
Article Abstract:
Mutations in regulatory genes containing homeobox genes in vertebrates is implicated in the evolution of ontogenetic patterns resulting in anatomical features different from those of invertebrates. This was inferred from comparative studies of the sequences and expression patterns of homeobox genes in representative vertebrates and invertebrates, in particular those controlling the formation of the neural crest, organogenesis and craniofacial morphogenesis.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 1992
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