Growth rate control of protein and nucleic acid content in Streptomyces coelicolor A3(2) and Escherichia coli B/r

Article Abstract:

Regulation of macromolecular content by specific growth rate in S. coelicolor A3(2) appears to be similar to that of Escherichia coli B/r in at least three aspects. First, most of the biomass is comprised of macromolecules, with protein accounting for the biggest part, followed by RNA and DNA having the smallest portion. Second, the ratios of the macromolecules change with specific growth rate, with the protein concentration decreasing, RNA concentration increasing and DNA concentration decreasing as the specific growth rate increases. Third, the RNA part shows the greatest relative change with specific growth rate.

Escherichia coli, Proteins, Nucleic acids

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The regulation of antibiotic production in Streptomyces coelicolor A3(2)

Article Abstract:

Microbiologist Mervyn Bibb discusses the progress made in studying the genetic and molecular mechanisms of regulation of antibiotics synthesis by Streptomyces. DNA cloning studies provide evidence for the presence and extent of clustering of the biosynthetic genes. Several gene clusters have pathway-specific regulatory genes with most of them probably functioning as transcriptional activators. S. coelicolor has genes with pleiotropic effects on antibiotic production, some of which have regulatory function. A diffusible factor affects initiation of antibiotic synthesis.

Antibiotics, Cloning, Speeches, lectures and essays, Transcript, Bibb, Mervyn

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Experimental verification of a mathematical model for pelleted growth of Streptomyces coelicolor A3(2) in submerged batch culture

Article Abstract:

Previous research has suggested the use of a finite element model to study pellet growth in a filamentous microorganism population. The model is tested by comparing its predictions with experimental data on growth of Streptomyces coelicolor in liquid batch culture. However, the model fails to correctly describe changes in pellet growth, necessitating its modification. The modified model's predictions agree closely with the experimental data, although it still fails to accurately describe final biomass concentration and the effects of autolysis on pellet growth.

Usage, Molds (Fungi), Finite element method

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