Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks

Article Abstract:

The mechanisms of Crb2 recruitment to DNA double-strand breaks (DSBs) is explored by analyzing the phenotypes of fission yeast mutants defective in histone modifications and examining Crb2 relocalization in these mutants using live-cell microscopy and chromatin immuniprecipitation (ChIP). It is proposed that such dual recruitment mechanisms may be a common feature of DNA damage checkpoint mediators.

Cell cycle, Methyltransferases

---

Histone deposition protein Asf1 maintains DNA replisome integrity and interacts with replication factor C

Article Abstract:

A demonstration shows the manner in which chromatin assembly factor Asf1 also affects DNA replication. The histone chaperone protein Asf1 maintains a subset of replication elongation factors at stalled replication forks and directly interacts with the replication machinery.

---

Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication

Article Abstract:

The physical association and functional cooperation between two epigenetic factors, DNMT1 and G9a, during DNA replication is described. The direct cooperation between DNMT1 and G9a has provided a mechanism of coordinated DNA and H3K9 methylation during cell division.

Cell division, Methylation, Report

Similar abstracts:

• Abstracts: Combining culture-dependent and -independent methodologies for estimation of richness of estuarine bacterioplankton consuming riverine dissolved organic matter
• Abstracts: Distinctions between c-Rel and other NF-kB proteins in immunity and disease. The many colours of chromodomains
• Abstracts: The pattern of gene amplification is determined by the chromosomal location of hairpin-capped breaks. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
• Abstracts: Development and evaluation of a reflective solar disinfection pouch for treatment of drinking water. Removal of astrovirus from water and sewage treatment plants, evaluated by a competitive reverse transcription-PCR
• Abstracts: African-derived South American populations: a history of symmetrical and asymmetrical matings according to sex revealed by bi- and uni-parental genetic markers

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.