Unproductively spliced ribosomal protein mRNAs are natural targets of mRNA surveillance in C. elegans

Article Abstract:

Unproductively spliced ribosomal protein mRNAs are natural targets of mRNA surveillance in C. elegans.

Genetic regulation, Nematoda, Nematodes, Ribosomal proteins

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PIE-1 is a bifunctional protein that regulates maternal and zygotic gene expression in the embryonic germ line of Caenorhabditis elegans

Article Abstract:

PIE-1 has been found to be a bifunctional protein regulating maternal/zygotic gene expression in the Caenorhabditis elegans embryonic germ line. It promotes germ cell fate by two mechanisms independent of one another.

Carrier proteins, Transport proteins, Genetic transcription, Transcription (Genetics), Embryology, Experimental, Embryological research, Antibody diversity, Zygotes, Zygote

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Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay

Article Abstract:

Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase has been found to associate with components of the mRNA surveillance complex. It is involved in the regulation of nonsense-mediated mRNA decay (NMD) and is a human ortholog of a product of Caenorhabditis elegans smg-1, which is one of its smg genes involved in NMD. A critical role in NMD is played by hSMG-1 through direct phosphorylation of hUPF1/SMG-2.

Japan, Human genetics, Protein kinases

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