Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis

Article Abstract:

The molecular basis of the antimicrobial activity in human airway surface fluid (ASF) which is defective in cases of cystic fibrosis (CF) was investigated using a human bronchial xenograft as the experimental model system. The results confirmed that the human beta-defensin (hBD-1) gene which encodes a protein product with salt-dependent antimicrobial activity is the one responsible for the bacterial killing effect of the ASF. hBD-1 thus plays an important role in the natural immune defense mechanism of the body.

Analysis, Cytochemistry, Cystic fibrosis, Xenotransplantation, Natural immunity

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LIN-10 is a shared component of the polarized protein localization pathways in neurons and epithelia

Article Abstract:

The PDZ protein LIN-10 is needed for localizing GLR-1 to the ASH-to-interneuron synapses. It has been established that LIN-10 is a shared component of the polarized protein-sorting pathways in epithelia and neurons. Furthermore, it has been shown that PDZ proteins are needed for localization of a neurotransmitter receptor to central synapses in vivo. It is possible that different neurotransmitter receptors are recruited to the ASH-to-interneuron synapses through the action of distinct PDZ proteins.

Neurotransmitter receptors

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