ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP

Article Abstract:

Various properties, including the interferon, genotoxic stress and pathogen infection are highly responsible for activating the protein modification by ISG15 (ISGylation), the ubiquitin-like molecule that plays a very important role in the innate immune responses. The analysis states that the ISGylation of 4EHP, an mRNA cap structure-binding protein, is very essential and highly affects the cap-structure dependent translation control in several immune responses.

Author: Dong-Er Zhang, Okumura, Fumihiko, Weiguo Zon
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
Biological Product (except Diagnostic) Manufacturing, Biological products exc. diagnostic, Interferon, Messenger RNA, Ubiquitin, Structure, Clinical report

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TAp63? induces AP-2? as an early event in epidermal morphogenesis

Article Abstract:

The role of the transcription factor TAp63? in promoting expression of AP-2? gene which leads to the development of epidermis in vertebrate embryos is studied.

Author: Williams, Trevor, Roop, Dennis R., Kim, Soeun, Koster, Maranke I., Huang, Jian
Publisher: Elsevier B.V.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 2006
United States, Genetic aspects, Growth, Vertebrates, Embryology, Experimental, Embryological research, DNA binding proteins, Epidermis, Company growth

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Subjects list: Research
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