Identification of a novel mechanism of regulation of Ah (dioxin) receptor function
Article Abstract:
A novel regulation mechanism of Ah, or dioxin, receptor function has been found. Ah receptor (AhR), a ligand-activated transcription factor, mediates pleiotropic effects on host animals of environmental pollutants, among them 2,3,7,8-tetrachlorodibenzo-p-dioxin. Besides induction of drug-metabolizing enzymes, the liganded AhR complex activates gene expression of a factor called AhR repressor (AhRR). AhRR inhibits AhR function, competing with AhR for binding to the XRE sequence and dimerizing with AhR nuclear translocator (Arnt). AhRR and AhR make up a regulation circuit in the xenobiotic signal transduction path and give a novel regulation mecahnism for AhR function. Possibly it determines tissue-specific pollutant sensitivity.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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Enhancer control of V(D)J recombination at the TCR-beta locus: differential effects on DNA cleavage and joining
Article Abstract:
Almost complete inhibition of V(D)J recombination at the TCR-beta locus and a block in alpha-beta T cell development result from deletion of the TCR beta transcriptional enhancer (E beta). The idea has been tested that V(D)J recombination is promoted by transcriptional enhancers through regulating accessibility of the locus to the recombinase. Loss of accessibility by itself does not account for the loss of TCR beta recombination when the E beta element is absent. It seems an additional function for E beta exists during the late phase of the recombination reaction in the process of DNA repair at certain TCR beta sites.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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