Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption

Article Abstract:

The identification of a proton-coupled, electrogenic, high-affinity folate transporter with properties that are similar to folate transport in intestinal and other cells at low pH is described. It is established that a major function of pH-independent heme carrier protein, HCP1 gene product is proton-coupled folate transport required for folate homeostasis in man, named PCFT/HCP1.

Genetic aspects, Folic acid, Carrier proteins, Transport proteins, Malabsorption syndromes, Structure, Chemical properties, Report

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Identification of a human heme exporter that is essential for erythropoiesis

Article Abstract:

FLVCR, a member of the major facilitator superfamily of transporter proteins, is the cell surface receptor for feline leukemia virus, subgroup C. It is demonstrated that human FLVCR exports cytoplasmic heme and it is hypothesized that human FLVCR is required on developing erythroid cells to protect them from heme toxicity.

Heredity, Human, Human heredity, Erythropoiesis, Feline leukemia

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At the crossroads of inflammation and cancer

Article Abstract:

Chronic inflammation and cancer are closely associated in the intestine. Anti-inflammatory medication reduces intestinal neoplasia, while colorectal cancer incidence is increased in ulcerative colitis.

Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Antiinflammatory Drugs, Health aspects, Risk factors, Colorectal cancer, Cancer, Ulcerative colitis, Anti-inflammatory drugs, Anti-inflammatory agents

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