Impact of heterologus expression of Escherichia coli UDP-glucose pyrophosphorylase on trehalose and glycogen synthesis in Corynebacterium glutamicum
Article Abstract:
The disaccharide called Trehalose has multiple uses in the food industry, and recently in 2004 a new mechanism is put forth to create trehalose depending on the improvement in strains of the gram positive bacterium Corynebacterium glutamicum. The outcome of this indicates that UDP-glucose forms an essential part both in the OtsBA and the TreYZ pathways.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2004
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Metabolic engineering of Corynebacterium glutamicum for trehalose overproduction: Role of the TreYZ trehalose biosynthetic pathway
Article Abstract:
The microbiological production methods based on the capacity of Corynebacterium glutamieum to excrete trehalose are explored. Expression of galU/treY and galU/treYZ synthetic operons showed a partial recovery in the intracellular glycogen levels and a significant improvement in both intra- and extracellular trehalose content.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2006
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Osmotic stress response: Quantification of cell maintenance and metabolic fluxes in a lysine-overproducing strain of Corynebacterium glutamicum
Article Abstract:
Osmotic stress reduces the efficiency and may lead to cell inactivation in industrial fermentations. The evaluation of the metabolic fluxes indicated that increased rate of dilution led to the recirculation of Cornybacterium glutamicum's metabolic fluxes, which benefited the development.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2004
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