The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1

Article Abstract:

An APC recognition signal, the KEN box, which is not the same as the D box targeted by Cdh1, is discussed. The sequence specificity for Cdh1-APC has been found using two assays. One is ubiquitination in a completely defined, purified system. The other is degradation promoted by Cdh1-APC in Xenopus extracts.

Proteins, Cell cycle, Proteolysis, Ligases, Protein denaturation

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Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulation Cdh1

Article Abstract:

A novel way to regulate Cdh1 on the part of the MAD2-related gene, MAD2L2, a spindle-assembly checkpoint protein, is discussed in this research communication. It appears that MAD2L2 and MAD2 inhibit substrate release from APC.

Genetic aspects, Mitosis

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Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex

Article Abstract:

Substrate recognition by Cdc20 and Cdh1, components of the anaphase-promoting complex, is discussed. Cdc20 and Cdh1 can bind with substrates using their N termini, which give specificity in a functional way, since they generate active chimeras that show the specificities.

Binding sites (Biochemistry), Active sites (Biochemistry)

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