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Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70

Article Abstract:

A major cellular protein associated with endogenous WT1 has been identified by immunoprecipitation and protein microsequencing analysis as the inducible chaperone Hsp70. WT1, the Wilms tumor suppressor, codes a zinc finger transcription factor expressed in glomerular podocytes during a short time period in kidney development. WT1 and Hsp70 are close in primary Wilms tumor specimens, in rat embryo kidney cells, and in cells in culture with inducible expression of WT1. It appears that Hsp70 is an important cofactor for WT1 and that the chaperone may be a factor during kidney differentiation.

Author: McCluskey, Robert T., Haber, Daniel A., DeCaprio, James A., Lee, Sean Bong, Englert, Christoph, Maheswaran, Shyamala, Zheng, Gang, Wong, Jenise, Harkin, D. Paul, Bean, James, Ezzell, Robert, Garvin, A. Julian
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
Research, Genetic regulation, Gene expression, Genetic transcription, Transcription (Genetics), Cell differentiation, Tumor suppressor genes, Kidney glomerulus, Glomeruli

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The bloody fate of endothelial stem cells

Article Abstract:

Thw authors review the publications on endothelial cells. The topics of interest include capturing elusive endothelial cells, and transcriptional programming of hematopoietic development.

Author: Kubo, Hajime, Alitalo, Kari
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2003
Finland, Analysis, Causes of, Endothelium, Stem cells, Leukemia, Hematopoiesis, Genetic research

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Subjects list: Genetic aspects
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