Abstracts » Biological sciences

Initial transformations in the biodegradation of benzothiazoles by Rhodococcus isolates

Article Abstract:

Research was conducted to examine the initial transformations in the biodegradation of benzothiazoles by Rhodococcus isolates. All pathways converge into 2-hydroxybenzothiazole (OBT) which was hydroxylated into diOHBT and was, subsequently, degraded further. It was apparent that the OBT and benzothiazol (BT) were closely related while benzothiazole-2-sulfonate (BTSO3) breakdown was not tested for strain PA. Results indicate that the BTSO3 degradation pathway overlaps or converges with the OBT and BT breakdown route.

Biodegradation, Bacterial transformation

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Acyl transfer activity of an amidase from Rhodococcus sp. strain R312: formation of a wide range of hydroxamic acids

Article Abstract:

Research was conducted to examine the formation of a wide range of hydroaximic acids with the enantioselective amidase from Rhodococcus sp. strain R312 which was produced in Escherichia coli and was purified in one chromatographic step. Results demonstrate that no acyl acceptors except hydroxylamine and water were found. The purified amidase was observed to be L-enantioselective towards alpha-hydroxy- and alpha-aminoamides.

Microbial enzymes, Amides

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Formation of a chiral hydroxamic acid with an amidase from Rhodococcus erythropolis MP50 and subsequent chemical lossen rearrangement to a chiral amine

Article Abstract:

Microbiological research shows that amidase from the organism Rhodococcus erythropolis MP50 has highly enantioselective acyltransferase activity. The enantiopure substances S-1-phenylethylamine is created from optically active 2-phenylpropionhydroxamate via a chemical Lossen rearrangement in an aqueous medium. The concentrations of 2-phenylpropionamide and 2-phenylpropionhydroxamate were established.

Phenethylamines, Enantiomers

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