Initiating cellular stress responses

Article Abstract:

The phosphoinositide 3-kinase related kinases (PIKKs) are responsible for generating responses to diverse stresses like deoxyribonucleic acid (DNA) double-strand breaks (DSBs), abnormal replication fork progression, recognition of premature termination of codons in messenger ribonucleic acid (mRNA) and insufficient nutrient availability. Cellular damage can be reduced and cell viability in the presence of stress can be promoted by using various control mechanisms to control the kinases.

Messenger RNA, Phosphoinositides, Phosphatidylinositols

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Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway

Article Abstract:

NBS1and BRCA1 that are required for the recruitment of activated ATM to the sites of DNA breaks after ionization irradiation is shown and that this recruitment is required for the phosporrylation of SMC1 by ATM. Observations suggested that many of the abnormal stress responses seen in cells lacking ATM, NBS1, or BRCA result from a failure of ATM migration to sites of DNA breaks and a resultant lack of SMC1 phosphorylation.

Phosphorylation

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Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA

Article Abstract:

The 3.1-Angstrom structure of the ternary complex formed by CSL, intracellular portion of the receptor Notch (NotchIC), and Mastermind bound to DNA is reported. Ternary complex formation induces a substantial conformational change within CSL, suggesting a molecular mechanism for the conversion of CSL from a repressor to an activator.

Conformational analysis, Crystals, Crystal structure, Structure

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