Intercellular trafficking and protein delivery by a herpesvirus structural protein
Article Abstract:
The herpes simplex virus type 1 (HSV-1) structural protein VP22 was found to have the remarkable capability of intercellular transport. This transport system is so efficient that after expression in a subpopulation the protein spreads to every cell in a monolayer where it concentrates in the nucleus and binds chromatin. Sensitivity to cytochalasin D treatment indicated that VP22 uses a unique trafficking pathway that involves the actin cytoskeleton.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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Intercellular connections are developmentally controlled to help move molecules through the plant
Article Abstract:
Studies have confirmed that small solutes such inorganic ions and sugars are able to diffuse readily through a plant's plasmodesmata. However, it also possible for certain viruses to pass through it and circumvent the plant's physical defenses. Azide was found to increase the permeability of the plasmodesmata. Virus genomes were found to pass through the plasmodesmata only when certain movement proteins are present.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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Simple, but not branched, plasmodesmata allow the nonspecific trafficking of proteins in developing tobacco leaves
Article Abstract:
A study was conducted to analyze the permeability of plasmodesmata in leaves undergoing the sink-source transition. Transgenic tobacco plants that express GFP under control of the AtSUC2 promoter were utilized. The leaves were imaged under the confocal microscope. Results indicated that nonspecific macromolecular trafficking is a general characteristic of simple plasmodesmata in sink leaves.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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