Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1
Article Abstract:
Protein kinase such as the casein kinase Ialpha and MEKK1 have synergic roles in suppressing NF-AT. MEKK1 protein kinase indirectly suppresses NF-AT4 nuclear import while casein kinase Ialpha directly binds and phosphorylates the transcription factor NF-AT4 which resulted to the inhibition of the transcription factor's nuclear translocation. These transcriptional factors have important function in maintaining and enhancing the masking activity responsible in controlling NF-AT4.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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HTVL-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation
Article Abstract:
A study was conducted to determine the role of HTLV-I transforming and transactivating protein in the activation of NF-kappaB, which is regulator of the cells inflammatory and immune response. It is observed that the activity of MEEK1 protein kinase is stimulated when Tax bids with the amino terminus of the protein kinase. Results also revealed that the direct interactions of Tax and MEKK1 can be attributed to tax-mediated increases in NF-kappaB nuclear translocation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
Article Abstract:
A study was conducted on the gene encoding protein p73. p73 maintains a similar homology to p53, a tumor suppressing protein, and maps to 1p36. Coding sequence mutations in p73 alleles were not observed in examinations of neuroblastoma cell lines with p73 and 1p heterozygosity losses. The monoallelical expression of p73, however, suggests that it a candidate gene in neuroblastoma and that it may interact with p53 and activate p53 target genes.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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