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Biological sciences

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Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression

Article Abstract:

Study results show that the first evidence that SMRT-mediated repression is promoted by class I and class II histone deacetylases. That SMRT can recruit class II histone deacetylases in an mSin3A-independent way has also been demonstrated. HDAC7 can interact with mSin3A in yeast and in mammalian cells. That suggests association of multiple repression complexes. A two-hybrid screen on SMRT-interacting proteins brought isolation of the recently described HDAC5 and a new family member called HDAC7. SMRT is a transcriptional corepressor that mediates the repressive effect of transcription factors that work in various signal pathways.

Enzymes, Saccharomyces, Cell differentiation, Mammals

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Sharp, an inducible cofactor that integrates nuclear receptor repression and activation

Article Abstract:

A novel SMRT-interacting protein now named SHARP (SMRT/HDAC1 Associated Repressor Protein) has been identified. Sharp, an inducible cofactor integrating nuclear receptor repression/activation, is discussed. A yeast two-hybrid screen which used the conserved carboxyl terminus of SMRT, a nuclear receptor corepressor, as a bait preceded isolation of SHARP, a potent transcriptional repressor whose repression domain interacts directly with SMRT and at least five members of the NuRD complex including HDAC1.

Statistical Data Included, Usage, Hormone receptors, Hormones, Cloning, RNA, Steroids (Drugs)

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A histone deacetylase corepressor complex regulates the Notch signal transduction pathway

Article Abstract:

The Delta-Notch signal transduction pathway performs numerous roles in animal development. It seems to regulate cell fate. Before induction CBF1/RBP-J-kappa interacts with a corepressor complex in which there is silencing mediator of retinoid and thyroid hormone receptors (SMRT) and histone deacetylase HDAC-1. A novel genetic switch can be seen in which status of important nuclear cofactor complexes is controlled by out-of-cell ligands.

Histones, Cell cycle

Similar abstracts:

• Abstracts: Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway

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