Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos

Article Abstract:

The transmembrane protein Notch (N) in Drosophila melanogaster undergoes ligand-dependent processing that generates intercellular derivatives that are phosphorylated and soluble. Transcription can be activated by N's cytoplasmic domain when connected directly to DNA. Some functions of N can be performed by a viral activator joined to Suppressor of Hairless (Su(H)) during embryogenesis. Relative amounts of Delta, N and Su(H) appear to control nuclear entry of N/Su(H) complex.

Author: Young, Michael W., Kidd, Simon, Lieber, Toby
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
Genetic regulation, Genetic transcription, Transcription (Genetics)

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Miranda mediates asymmetric protein and RNA localization in the developing nervous system

Article Abstract:

Asymmetric stem cell divisions take place in neuroblasts to generate ganglion mother cells (GMCs) in a series. The cell fate determinant Prospero is partitioned asymmetrically to the GMC by Miranda protein. Miranda ties Prospero to the basal cortex of the neuroblast as it is dividing. The protein mediates asymmetric RNA and protein localizing in the nervous system as it develops.

Author: Brand, Andrea H., St Johnston, Daniel, Schuldt, Alison J., Adams, Jan H.J., Davidson, Catherine M., Micklem, David R., Haseloff, Jim
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
Research, Growth, Nervous system, RNA, Stem cells

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Subjects list: Genetic aspects, Drosophila
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