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Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons

Article Abstract:

Neuroligin expressed in nonneuronal cells has been found to trigger presynaptic development in contacting axons. Through use of an in vitro system it was shown that neuroligin-1 and -2 are able to trigger the de novo formation of presynaptic structure. It seems neuroligins are part of the mechanism used in formation/remodeling of CNS synapses. Neuroligin-1 and -2 are postsynaptically localized proteins

Author: Scheiffele, P., Fan, J., Choih, J., Fetter, R., Serafini, T.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
Central nervous system, Cytogenetics, Synapses

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Lateral signaling mediated by axon contact and calcium entry regulates asymmetric odorant receptor expression in C. elegans

Article Abstract:

Regulation of asymmetric odorant receptor expression in Caenorhabditis elegans by lateral signaling mediated by axon contact and calcium entry is discussed. Study of str-2, a predicted seven-transmembrane domain protein with sequence similarity to the diacetyl receptor odr-10, expression shows that alternative olfactory cell fates can be specified by calcium channels and CaM kinase.

Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
Statistical Data Included, Caenorhabditis elegans, Olfactory nerve

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Subjects list: Research, United States, Genetic aspects, Cytochemistry, Axons, Neurons
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