Lhx2-decisive role in epithelial stem cell maintenance, or just the "tip of the iceberg"?

Article Abstract:

Lhx2 is identified as a transcription factor functionally positioned downstream of signals that is necessary to specify hair follicle stem cells. The epithelial stem cells are a key target for carcinogenic and mutagenic agents and are capable of regenerating all types of skin epithelia, including the epidermis besides their role for hair growth and hair regeneration.

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Cylindromatosis and the CYLD gene: new lessons on the molecular principles of epithelial growth control

Article Abstract:

An analysis of cylindromatosis and the associated defects in the CYLD gene is providing novel insights into the molecular principles of epithelial growth control and carcinogenesis in, and beyond, the skin. Recent insights into CYLD function and cylindroma pathogenesis may lead to the development of novel molecular strategies for cancer prevention and treatment.

Cancer, Cancer genetics, Tumor suppressor genes, Genetic research, Epithelial tumors, Tumour suppressor genes, Epithelial tumours

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Continous tooth replacement : the possible involvement of epithelial stem cells

Article Abstract:

A study indicates involvement of epithelial stem cells in the continuous tooth replacement that characterizes non-mammalian vertebrates. Arguments on observation of tooth renewal in the zebra fish and on the similarities between molecular control of hair and tooth formation are discussed.

Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Dental Research

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