Life without white fat: a transgenic mouse
Article Abstract:
A transgenic mouse with no white adipose tissue (WAT) at any time in its life has been generated. WAT is the major organ for regulating storage of triglycerides in the body where they are used for metabolic energy. Physiological consequences of total lack of WAT are profound. The mice express a dominant-negative protein which is controlled by the adipose-specific aPw enhancer-promoter. The protein stops DNA binding of B-ZIP transcription factors of the Jun and CCAAT/enhancer-binding protein (C/EBP) families. It appears that the A-ZIP/F-1 phenotype can be a mouse model for lipoatrophic diabetes in humans. It seems lack of fat can bring on diabetes.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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Reconstitution of a minimal RNA degradosome demonstrates functional coordination between a 3' exonuclease and a DEAD-box RNA helicase
Article Abstract:
The authors focus on a method for reconstituting a minimal degradosome from purified proteins active against DNA substrates. The mechanisms for Rh1B-activated degradation of structured RNA by degradosome from Escherichia coli are presented.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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