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Lineage commitment in the immune system: the T helper lymphocyte grows up

Article Abstract:

The T helper lymphocytes and their function in the immune system are discussed in this review article. The current knowledge of signals that regulate lineage commitment in T helper cells is summarized with emphasis on three subset-specific transcription factors responsible for lineage commitment. They are T-bet, c-Maf and GATA-3. Topics include cytokines, development of the Th1 lineage and signaling pathways, interferons in the Th1 responses, APC, antigen and costimulation.

Author: Glimcher, Laurie H., Murphy, Kenneth M.
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
Physiological aspects, DNA, Chromatin, Developmental biology, Cellular signal transduction, Embryology, Experimental, Embryological research, Cell differentiation, T cells, Cytokines

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PGC-1[alpha] regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy

Article Abstract:

The transcription of a neuromuscular junction gene is enhanced by the phosphorylation of PGC-1[alpha] and GA-binding protein. The control extended by the coactivator PGC-1[alpha] is found to be vital in the treatment of Duchenne muscular dystrophy.

Author: Spiegelman, Bruce M., Seale, Patrick, Campbell, Kevin P., Handschin, Christoph, Kobayashi, Yvonne M., Sherry Chin
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
Science & research, Care and treatment, Genetic aspects, Neuromuscular junction, Duchenne muscular dystrophy

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Transcriptional regulation of adipogenesis

Article Abstract:

Research has been conducted on the molecular regulation of differentiation for specific cell types. The results of the experiments with the adipose tissue are described.

Author: Spiegelman, Bruce M., Rosen, Evan D., Walkey, Christopher J., Puigserver, Pere
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
Statistical Data Included, Analysis, Adipose tissues, Adipose tissue, Fat cells, Adipocytes

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Subjects list: Research, United States, Genetic transcription, Transcription (Genetics), Heredity
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