Links in the left/right axial pathway
Article Abstract:
Recent developments have helped shed light on the left/right axial pathway in the development of asymmetry among vertebrates. This pathway can be traced from the egg and the differential expression of genes that dictate laterality in embryologic development. Although the earliest origin of the left/right pathway is unknown, a number of differentially expressed genes have been discovered. Further, the node of Ranvier in avian embryos has been shown to be an important structure in the determination of laterality.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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Reorganizing the organizer 75 years on
Article Abstract:
The year 1999 marks the 75th anniversary of what is considered a turning point in the evolution of experimental embryology. It was at that point in time when Spemann and Mangold succeeded in transplanting the blastopore lip of a newt gastrula into a second embryo that eventually generated another embryo. That experiment paved the way for the discovery of similar structures in all vertebrates, including the embryonic shield in fish, the Hensen's node in chick and the node in the mouse.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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Antagonists go out on a limb
Article Abstract:
This review discusses recent advances in the area of how vertebrate limbs control their distal growth. The Meis-Pbx gene interaction confers proximal status to the early limb bud followed by maintenance of the limb's distal determinant by the interaction of BMPs, Gremlin factors and Hoxd proteins.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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