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Mechanisms of Hox gene colinearity: transposition of the anterior Hoxb1 gene into the posterior HoxD complex

Article Abstract:

Transposition of the anterior Hoxb1 gene into the posterior HoxD complex is discussed relative to mechanisms of Hox gene colinearity. To gain insight into the ways down-regulation seen in transgene relocation in the posterior HoxD complex and to better understand the mechanisms behind colinearity, transposing the anterior Hoxb1 transgene to the back end of HoxD was undertaken. Strong repression expected was not seen in the early mesoderm domain in which the transgene was transcribed in a way like that of its endogenous counterpart. A repressive mechanism may not be implemented at the same level in all tissues. Position in the gene in a complex is not responsible entirely for time of activation.

United Kingdom, Usage, Brain, Vertebrates, Developmental biology, Cytochemistry, Embryology, Experimental, Embryological research, Cell differentiation, Genetically modified organisms, Gastrulation

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Localized and transient transcription of Hox genes suggests a link between patterning and the segmentation clock

Article Abstract:

Results indicate that Hox gene activation and the segmentation clock are molecularly linked facilitating production of segments with morphological specification. Data show that Hoxd1 and other Hox genes mediate expression of dynamic stripes within presomitic mesoderm.

Italy, Analysis, Cellular signal transduction

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Gene transpositions in the HoxD complex reveal a hierarchy of regulatory controls

Article Abstract:

Gene transpositions in the HoxD gene complex indicate that the activation of Hox genes are under high order control and reveal three functional restrictions linked to the conservation of Hox gene clustering. The introduction of two Hoxd transcription units labeled with lacZ to an ectopic 5' position in the HoxD complex results in delay in early expression of the relocated genes. The transposed genes act like the neighbouring Hoxd-13 genes. Locus-dependent expression in genital eminence and distal limbs occurs at later stages.

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