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Biological sciences

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Locations of human genes for alpha-1A, alpha-1B and alpha-1E calcium channels determined by radiation hybrid mapping

Article Abstract:

Detailed investigation of the locations of human calcium channel alpha-1 subunit genes, CACNL1A4 (alpha-1A), CACNL1A5 (alpha-1B) and CACNL1A6 (alpha-1E) has produced results confirming the earlier mapping of human alpha-1A, alpha-1B and alpha-1E calcium channels to chromosomes 19q13, 9q34 and 1q25-q31 respectively. It was also possible to confirm the identity of the polymerase chain reaction products to the target genes by sequencing them. The sequence data made it possible to find restriction enzyme length polymorphism in the alpha-1A and alpha-1E calcium channel genes between the human and hamster.

Calcium channels

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A new mutant rat with hyperbilirubinuria (hyb)

Article Abstract:

A new mutant rat strain shows jaundice and hyperbilirubinuria after birth. The affected homozygous male rats had complete reproductive capacity but double recessive male to double recessive female pairs were less productive especially in the second parturition. Jaundice is found in the rats throughout their lives. The size of male offsprings remained the same but the size of females decreased. The mutation is a single autosomal recessive gene with full penetrance and two mutant strains with the jaundice and hyperbilirubinuria were allelic despite phenotypic differences.

Diseases

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A new mutant rat with turning behaviour (Tur)

Article Abstract:

Circling or turning behavior in response to extroceptive stimuli is found in a new rat strain. Mutant conditions were created by crossing brothers and sisters of the species and the offspring exhibited the same behavior, creating the congenic strain, WKY/Eis-Tur. The study reveals that there is no abnormality in the cerebrum, cerebellum or posterior, lateral or anterior semicircular canals of the rat. The mutation is an autosomal dominant gene.

Behavior

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