Loss of circadian rhythmicity in aging mPer1 (super)-/- mCry2 (super)-/- mutant mice

Article Abstract:

Research has been conducted on mPer1, mPer2, mCry1 and mCry2 genes which are important in the molecular mechanism driving mammalian circadian clock's central pacemaker. Results demonstrate that the loss of rhythmicity is caused by altered expression regulation of core clock components, and that the amount of mPER and mCRY proteins and the composition of mPER and mCRY complexes are critical for circadian rhythm generation and maintenance.

Netherlands, Switzerland, Circadian rhythms, Life cycles (Biology)

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The yeast SAS (something about silencing) protein complex contains a MYST-type putative acetyltransferase and functions with chromatin assembly factor ASF1

Article Abstract:

Research has been conducted on the histone and nonhistone protein acetylation linked to the transcriptional activation and gene silencing regulation. The effect of the mutations in the Sas2p acetyl CoA binding site on the silencing in vivo has been investigated and the results are presented.

Japan, Statistical Data Included, Histones, Chromatin

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RNA polymerase mutations that impair conversion to a termination-resistant complex by Q antiterminator proteins

Article Abstract:

Research has been conducted on bacteriophage lambda Q-protein which binds RNA polymerase to a termination-resistant form. The authors have investigated amino acid substitutions in this polymerase which disrupts Q-mediate antitermination, and discuss the results.

Bacteriophages, Developmental biology, RNA polymerases

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